The US Department of Energy (DOE) has announced $159 million in awards for 12 Phase II projects under the Genesis Mission. The projects aim to advance Super Intelligence (SI) for science.
President Donald Trump launched the Genesis Mission in November 2025 to accelerate discovery and strengthen US leadership in science, medicine and technology. Its first-year portfolio includes 297 projects.
The projects bring together national laboratories, universities and industry partners. They will combine SI with scientific data, supercomputing and DOE research infrastructure to accelerate discoveries.
The selected work includes building a digital twin for a fusion demonstration device, expanding an RNA structure database, advancing particle physics research, mapping geothermal reservoirs and improving the extraction of rare-earth elements.
Other projects will develop tools for enzyme design and microchips for extreme environments, support particle accelerator operations, address error correction in quantum computing and optimize scientific software for supercomputers.
The new selections bring the total number of Phase II projects to 14. Previously announced awards include GridFM 2.0 under the Office of Electricity and Prometheus under the Office of Nuclear Energy.
DOE also selected six new Phase I projects, expanding the Genesis Mission’s initial round. Details about these and previously selected projects are available on the department’s website.
